Istron Bay Hotel is located in the northeastern part of the island of Crete, 13kms (8,1miles) from Agios Nikolaos and only 880m(0,6miles) from Istron village, famous for its beautiful beaches, many tavernas, shops and bars. Istron Bay Hotel is only 13,5kms (8,4miles) away from the picturesque village of Kalo Horio.

The Hotel complex is 70kms(43,5miles) from Heraklion port and airport, 60kms(37,3miles) from Sitia and 22kms(13,7miles) from the southernmost city in Europe, Ierapetra.